Epipox is a resource customized for epitope vaccine design against pathogenic orthopoxviruses.
The database is built upoen predicted T cell epitopes covering 124 proteins that are shared between the following
The list of proteins that are equivalent between the selected orthopoxvirus can be obtained here
EPIPOX contains both CD4 and CD8 T cell epitopes that have been predicted using peptide-MHC I and II binding profiles, respectively . In particular, we used 32 HLA I and 33 HLA-II specific matrices. Users can select single of combination of HLA I molcules to retrieve the relevant T cell epitoptes. Here follow the list of HLA molecules in EPIPOX:
A2: A*0201, A*0202, A*0203, A*0205, A*0206, A*0207, A6802 A3: A*0301, A*1101, A*3101, A*3301, A*6801, A*6601 A24: B*0702, B*3501, B*5101, B*5102, B*5301, B*5401
The alleles belogning to these supertypes are present in 88 % of the population regardless of their ething groups. Selecting promiscous peptides restricted by these 3 supertypes facilitate maximizaing the population coverage of vaccines with minimum number of peptides. For more details check Reche & Reche, NAR, 2005: W138-42
T cell epitopes searches results in EPIPOX can be limited by several criteria, including temporal expression of genes and features of antigens: